Projeted Growth
Moderate

Growth Potential Meter

High Mobility Group Protein B1 Market by Product Type (Dociparstat Sodium, RBM-005, EV-007156) by Application / End /User (Autoimmune Disorders, Cerebral Infarction, Chemotherapy Effects, Cancer) Industry Analysis, Volume, Share, Growth,Challenges,Key Players, Trends, Regions and Forecast 2016

Number of pages: 151 | Report Code: PSMR- PSMR-000104 | Report Format : PDF

Report Coverage

Parameters Details

Base Year

2021

Historical Data

2016-2021

Forecast Data

2022-2028

Base Year Value (2021)

USD million

Forecast Value (2028)

USD million

CAGR (2022 to 2028)

%

Regional Scope

North America, Europe, Asian Pacific, Latin America, Middle East and Africa, and ROW

High Mobility Group Protein B1 (HMGB1) also known as High mobility group box 1 or SBP-1 is protein encoded by HMGB1 gene. HMGB1 is secreted by immune cells such as monocytes , macrophages, and dendritic cells through leaderless secretory pathway. Activated macrophages and monocytes secrete HMGB1. High Mobility Group Box protein 1 (HMGB1) is a non-alkaline (non-histonic) DNA-binding protein, it is normally localized in the nucleus as part of the chromatin. High Mobility Group Protein B1 is member of chromatin proteins which also includes , HMG1, HMG 2, HMG 14, and HMG 17.  


HMGB1 with its high positive charge binds to DNA leads to oxidation, hyperacetylation and posttranslational modifications. HMGB1 is responsible for Stabilization of the nucleosomal structure and regulation of gene transcription in chromatin. It is released by necrotic cells hence act as chaperone to shuttle nuclei acids into the endosomal compartment of APCs. Nucleic acid sensors like TLR9 trigger due to High Mobility Group Protein B1 (HMGB1) . HMGB1 also has the ability to bind LPS, at the level of lipid A, possibly because of its high positive electric charge. It can chaperone to the CD14-TLR4 MD2 complex, increasing the response of macrophages to the LPS.  


High Mobility Group Protein B1 (HMGB1) has its importance in:

  • Cellular processes such as inflammation, cell differentiation and tumor cell migration.
  • Clearance of apoptotic cells, such as in autoimmune diseases
  • Splicing results in multiple transcript variants that encode the same protein.
  • Antibodies that neutralize HMGB1 can be used to protects against damage and tissue injury during arthritis, lupus erythematosus, colitis, sepsis, endotoxemia, and ischemia.
  • thermodynamic stability with electrostatic interactions between the acidic tail and the HMG box.
  • The C-terminal acidic tail of HMGB1 helps in the maintenance of protein stability.

High Mobility Group Protein B1 Market : Key Player

  • Affibody AB
  • Cantex Pharmaceuticals Inc
  • Dicerna Pharmaceuticals Inc
  • Evec Inc
  • Ribomic Inc

High Mobility Group Protein B1 Market: End User / Application Type

  • Autoimmune Disorders
  • Cerebral Infarction
  • Chemotherapy Effects
  • Cancer Treatment

High Mobility Group Protein B1 Market : Product Type

  • Dociparstat Sodium
  • RBM-005
  • EV-007156

Global High Mobility Group Protein B1 Market: Regional Analysis

  • North America
    • U.S.A
    • Canada
  • Europe
    • France
    • Germany
    • Spain
    • UK
    • Rest of Europe
  • Asia Pacific
    • China
    • Japan
    • India
    • South East Asia
  • Latin America
    • Brazil
  • Middle East and Africa

High Mobility Group Protein B1 Market Report delivers comprehensive analysis of :

  • Market Forecast for 2018-26
  • Market growth drivers
  • Challenges and Opportunities
  • Emerging and Current market trends
  • Market player Capacity, Production, Revenue (Value)
  • Supply (Production), Consumption, Export, Import analysis
  • End user/application Analysis


Frequently Asked Questions (FAQ)


High Mobility Group Protein B1 Market was valued at around USD million in 2021 & estimated to reach USD by 2028.




High Mobility Group Protein B1 Market is likely to grow at compounded annual growth rate (CAGR) of % between 2022 to 2028.












Yes, the report includes COVID 19 impact on the market.



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