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High Mobility Group Protein B1 (HMGB1) also known as High mobility group box 1 or SBP-1 is protein encoded by HMGB1 gene. HMGB1 is secreted by immune cells such as monocytes , macrophages, and dendritic cells through leaderless secretory pathway. Activated macrophages and monocytes secrete HMGB1. High Mobility Group Box protein 1 (HMGB1) is a non-alkaline (non-histonic) DNA-binding protein, it is normally localized in the nucleus as part of the chromatin. High Mobility Group Protein B1 is member of chromatin proteins which also includes , HMG1, HMG 2, HMG 14, and HMG 17.
HMGB1 with its high positive charge binds to DNA leads to oxidation, hyperacetylation and posttranslational modifications. HMGB1 is responsible for Stabilization of the nucleosomal structure and regulation of gene transcription in chromatin. It is released by necrotic cells hence act as chaperone to shuttle nuclei acids into the endosomal compartment of APCs. Nucleic acid sensors like TLR9 trigger due to High Mobility Group Protein B1 (HMGB1) . HMGB1 also has the ability to bind LPS, at the level of lipid A, possibly because of its high positive electric charge. It can chaperone to the CD14-TLR4 MD2 complex, increasing the response of macrophages to the LPS.
High Mobility Group Protein B1 (HMGB1) has its importance in:
High Mobility Group Protein B1 Market : Key Player
High Mobility Group Protein B1 Market: End User / Application Type
High Mobility Group Protein B1 Market : Product Type
Global High Mobility Group Protein B1 Market: Regional Analysis
High Mobility Group Protein B1 Market Report delivers comprehensive analysis of :
| Parameters | Details |
|---|---|
Base Year | 2022 |
Historical Data | 2017-2022 |
Forecast Data | 2023-2029 |
Regional Scope | North America, Europe, Asian Pacific, Latin America, Middle East and Africa, and ROW |
High Mobility Group Protein B1 Market report considers 2021 as the base year.
High Mobility Group Protein B1 Market report considers data for period 2016 to 2021 as the historical data to predict market forecast between 2022 to 2029.
Yes, report is inclusive in-detailed analysis of key players in High Mobility Group Protein B1 Market
High Mobility Group Protein B1 Market Study is broadly divided into North America, Europe, Asian Pacific, Latin America, Middle East and Africa, and ROW. Also these regions are further analysed as per various countries
High Mobility Group Protein B1 Market Report includes Market Segmentation, Regional outlook, Application Analysis, Competitive analysis, Supply-Demand Analysis, Pricing insight.
Yes, the report includes COVID 19 impact on the market.
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